Chemo-profiling of methanolic and ether oleoresins of Salvia coccinea and in vitro pesticidal evaluation with in silico molecular docking and ADME/Tox studies

The objective of the present study was to examine chemical compositions Salvia coccinea oleoresins prepared in methanol and petroleum ether. GC-MS analysis methanolic oleoresin (SCMO) ether (SCEO) resulted identification 15 12 constituents, comprising 84.7 81.2% total composition, respectively. Both SCMO SCEO varied their composition terms quantity, namely, oleic acid (22.3-25.9%), palmitic (8.9-8.4%), stigmasta-3,5-dien-7-one (3.4-11.8%), stigmasterol acetate (3.5-5.3%), neophytadiene (4.8-1.7%), phytol (1.6-7.8%) phthalic (2.1-3.1%). In addition qualitative differences between concomitantly, both were examined for pesticidal activities. Oleoresins demonstrated significant nematicidal activity against Meloidogyne incognita, insecticidal Lipaphis erysimi, antifungal Curvularia lunata, antibacterial Staphylococcus aureus. For activity, exhibited a high mortality 65.66±1.69 54.33±1.24 egg hatching inhibition 26.33±1.20and 33.33±1.24 at 200 μg/mL. Similarly, excellent with 94.87±1.44 % 86.75±1.85 1000 However, moderate activities compared standards. Due quantitative difference presence several phytoconstituents that absent SCEO, displayed stronger effects than SCEO. To estimate binding energy structure-activity relationships constituents activities, silico molecular docking ADME/Tox studies have also been performed using web-based online tool. On basis study, it is inferred herb might be good source phytochemicals can used development herbal-based pesticides/formulations after proper clinical trials.